Researchers identify new drug that may reduce arthritis progression
| Jan 2, 2020, 12:54 IST
A team of scientists have discovered a drug that may help to reduce arthritis progression in osteoarthritis patients. The finding's of the new study were published in the journal Annals of Internal Medicine. Researchers from the University of Leeds in the UK made the discovery.
‘MIV-711’, a drug which researchers say is a selective cathepsin K inhibitor, has great potential to reduce disease progression in such patients. The team notes that it was not any more effective than the placebo when it comes to tackling pain associated with knee osteoarthritis.
Osteoarthritis of the knee is painful and the condition affects millions of people across the globe. Knee osteoarthritis pain occurs due to may pathologic processes that involve articular cartilage, subchondral bone, synovium, meniscus, and other joint structures. This causes joint failure.
The results of the study showed MIV-711 was linked with less bone remodelling and less cartilage volume loss. The team also found lower levels of bone resorption and collagen loss due to the drug. But when it comes to osteoarthritic knee pain, there was no effect that was beneficial. More research and experiments are needed to better understand how useful MIV-711 is to treat people.
Another study claims hormone therapy could be effective in treating knee osteoarthritis. "Past and current users of hormone therapy had a lower prevalence of knee joint osteoarthritis, suggesting that hormone therapy may be protective against knee osteoarthritis," Dr JoAnn Pinkerton, The North American Menopause Society (NAMS) executive director, told a news portal. Adding,"This study suggests that estrogen taken at menopause may inhibit cartilage damage and reduce knee deterioration seen on x-rays."
Picture Courtesy: Google Images
‘MIV-711’, a drug which researchers say is a selective cathepsin K inhibitor, has great potential to reduce disease progression in such patients. The team notes that it was not any more effective than the placebo when it comes to tackling pain associated with knee osteoarthritis.
Osteoarthritis of the knee is painful and the condition affects millions of people across the globe. Knee osteoarthritis pain occurs due to may pathologic processes that involve articular cartilage, subchondral bone, synovium, meniscus, and other joint structures. This causes joint failure.
The results of the study showed MIV-711 was linked with less bone remodelling and less cartilage volume loss. The team also found lower levels of bone resorption and collagen loss due to the drug. But when it comes to osteoarthritic knee pain, there was no effect that was beneficial. More research and experiments are needed to better understand how useful MIV-711 is to treat people.
Another study claims hormone therapy could be effective in treating knee osteoarthritis. "Past and current users of hormone therapy had a lower prevalence of knee joint osteoarthritis, suggesting that hormone therapy may be protective against knee osteoarthritis," Dr JoAnn Pinkerton, The North American Menopause Society (NAMS) executive director, told a news portal. Adding,"This study suggests that estrogen taken at menopause may inhibit cartilage damage and reduce knee deterioration seen on x-rays."
Picture Courtesy: Google Images